public class MedicationCorrelationOptions { public const string SectionName = "MedicationCorrelation"; /// Lookback window for medication-vital correlation (minutes). public int CorrelationWindowMinutes { get; set; } = 90; /// /// Drug name (lowercase) → observation codes that may be affected. /// Keys are normalized to lowercase for case-insensitive lookup. /// public Dictionary DrugVitalMappings { get; set; } = new() { // Beta-blockers ["metoprolol"] = new[] { "SYSTOLIC_BP", "HEART_RATE", "DIASTOLIC_BP" }, ["labetalol"] = new[] { "SYSTOLIC_BP", "HEART_RATE", "DIASTOLIC_BP" }, ["atenolol"] = new[] { "SYSTOLIC_BP", "HEART_RATE", "DIASTOLIC_BP" }, ["propranolol"] = new[] { "SYSTOLIC_BP", "HEART_RATE", "DIASTOLIC_BP" }, ["esmolol"] = new[] { "SYSTOLIC_BP", "HEART_RATE", "DIASTOLIC_BP" }, ["carvedilol"] = new[] { "SYSTOLIC_BP", "HEART_RATE", "DIASTOLIC_BP" }, // Vasopressors / inotropes ["norepinephrine"] = new[] { "SYSTOLIC_BP", "DIASTOLIC_BP", "HEART_RATE" }, ["epinephrine"] = new[] { "SYSTOLIC_BP", "DIASTOLIC_BP", "HEART_RATE", "GLUCOSE_MG_DL" }, ["vasopressin"] = new[] { "SYSTOLIC_BP", "DIASTOLIC_BP" }, ["dopamine"] = new[] { "SYSTOLIC_BP", "DIASTOLIC_BP", "HEART_RATE" }, ["dobutamine"] = new[] { "SYSTOLIC_BP", "HEART_RATE" }, ["phenylephrine"] = new[] { "SYSTOLIC_BP", "DIASTOLIC_BP", "HEART_RATE" }, // Calcium channel blockers ["diltiazem"] = new[] { "HEART_RATE", "SYSTOLIC_BP", "DIASTOLIC_BP" }, ["verapamil"] = new[] { "HEART_RATE", "SYSTOLIC_BP", "DIASTOLIC_BP" }, ["amlodipine"] = new[] { "SYSTOLIC_BP", "DIASTOLIC_BP" }, ["nicardipine"] = new[] { "SYSTOLIC_BP", "DIASTOLIC_BP", "HEART_RATE" }, // Antihypertensives ["nitroglycerin"] = new[] { "SYSTOLIC_BP", "DIASTOLIC_BP", "HEART_RATE" }, ["nitroprusside"] = new[] { "SYSTOLIC_BP", "DIASTOLIC_BP", "HEART_RATE" }, ["hydralazine"] = new[] { "SYSTOLIC_BP", "DIASTOLIC_BP", "HEART_RATE" }, // Opioids ["morphine"] = new[] { "RESP_RATE", "SPO2", "SYSTOLIC_BP", "HEART_RATE" }, ["fentanyl"] = new[] { "RESP_RATE", "SPO2", "HEART_RATE" }, ["hydromorphone"] = new[] { "RESP_RATE", "SPO2", "SYSTOLIC_BP" }, ["remifentanil"] = new[] { "RESP_RATE", "SPO2", "HEART_RATE" }, // Sedatives / anaesthetics ["propofol"] = new[] { "RESP_RATE", "SPO2", "SYSTOLIC_BP", "HEART_RATE" }, ["midazolam"] = new[] { "RESP_RATE", "SPO2" }, ["lorazepam"] = new[] { "RESP_RATE", "SPO2" }, ["ketamine"] = new[] { "HEART_RATE", "SYSTOLIC_BP", "RESP_RATE" }, // Antiarrhythmics ["amiodarone"] = new[] { "HEART_RATE", "SYSTOLIC_BP" }, ["adenosine"] = new[] { "HEART_RATE" }, ["digoxin"] = new[] { "HEART_RATE" }, ["atropine"] = new[] { "HEART_RATE" }, // Anticoagulants ["heparin"] = new[] { "HEART_RATE" }, // Antipyretics ["acetaminophen"] = new[] { "TEMP_C" }, ["ibuprofen"] = new[] { "TEMP_C" }, // Glucose management ["insulin"] = new[] { "GLUCOSE_MG_DL" }, ["dextrose"] = new[] { "GLUCOSE_MG_DL" }, ["glucagon"] = new[] { "GLUCOSE_MG_DL" }, // Corticosteroids ["dexamethasone"] = new[] { "GLUCOSE_MG_DL", "TEMP_C" }, ["methylprednisolone"] = new[] { "GLUCOSE_MG_DL", "TEMP_C" }, ["hydrocortisone"] = new[] { "GLUCOSE_MG_DL", "TEMP_C" }, ["prednisone"] = new[] { "GLUCOSE_MG_DL", "TEMP_C" }, // Diuretics ["furosemide"] = new[] { "SYSTOLIC_BP", "DIASTOLIC_BP" }, // Bronchodilators ["albuterol"] = new[] { "HEART_RATE", "SPO2" } }; }