feature: Medication Tracking & Vital Sign Correlation

2026-06-19 10:47:55 +08:00
parent e2d40331b7
commit 5c7e37471b
29 changed files with 2512 additions and 4 deletions
@@ -0,0 +1,83 @@
+public class MedicationCorrelationOptions
+{
+    public const string SectionName = "MedicationCorrelation";
+
+    /// <summary>Lookback window for medication-vital correlation (minutes).</summary>
+    public int CorrelationWindowMinutes { get; set; } = 90;
+
+    /// <summary>
+    /// Drug name (lowercase) → observation codes that may be affected.
+    /// Keys are normalized to lowercase for case-insensitive lookup.
+    /// </summary>
+    public Dictionary<string, string[]> DrugVitalMappings { get; set; } = new()
+    {
+        // Beta-blockers
+        ["metoprolol"]      = new[] { "SYSTOLIC_BP", "HEART_RATE", "DIASTOLIC_BP" },
+        ["labetalol"]       = new[] { "SYSTOLIC_BP", "HEART_RATE", "DIASTOLIC_BP" },
+        ["atenolol"]        = new[] { "SYSTOLIC_BP", "HEART_RATE", "DIASTOLIC_BP" },
+        ["propranolol"]     = new[] { "SYSTOLIC_BP", "HEART_RATE", "DIASTOLIC_BP" },
+        ["esmolol"]         = new[] { "SYSTOLIC_BP", "HEART_RATE", "DIASTOLIC_BP" },
+        ["carvedilol"]      = new[] { "SYSTOLIC_BP", "HEART_RATE", "DIASTOLIC_BP" },
+
+        // Vasopressors / inotropes
+        ["norepinephrine"]  = new[] { "SYSTOLIC_BP", "DIASTOLIC_BP", "HEART_RATE" },
+        ["epinephrine"]     = new[] { "SYSTOLIC_BP", "DIASTOLIC_BP", "HEART_RATE", "GLUCOSE_MG_DL" },
+        ["vasopressin"]     = new[] { "SYSTOLIC_BP", "DIASTOLIC_BP" },
+        ["dopamine"]        = new[] { "SYSTOLIC_BP", "DIASTOLIC_BP", "HEART_RATE" },
+        ["dobutamine"]      = new[] { "SYSTOLIC_BP", "HEART_RATE" },
+        ["phenylephrine"]   = new[] { "SYSTOLIC_BP", "DIASTOLIC_BP", "HEART_RATE" },
+
+        // Calcium channel blockers
+        ["diltiazem"]       = new[] { "HEART_RATE", "SYSTOLIC_BP", "DIASTOLIC_BP" },
+        ["verapamil"]       = new[] { "HEART_RATE", "SYSTOLIC_BP", "DIASTOLIC_BP" },
+        ["amlodipine"]      = new[] { "SYSTOLIC_BP", "DIASTOLIC_BP" },
+        ["nicardipine"]     = new[] { "SYSTOLIC_BP", "DIASTOLIC_BP", "HEART_RATE" },
+
+        // Antihypertensives
+        ["nitroglycerin"]   = new[] { "SYSTOLIC_BP", "DIASTOLIC_BP", "HEART_RATE" },
+        ["nitroprusside"]   = new[] { "SYSTOLIC_BP", "DIASTOLIC_BP", "HEART_RATE" },
+        ["hydralazine"]     = new[] { "SYSTOLIC_BP", "DIASTOLIC_BP", "HEART_RATE" },
+
+        // Opioids
+        ["morphine"]        = new[] { "RESP_RATE", "SPO2", "SYSTOLIC_BP", "HEART_RATE" },
+        ["fentanyl"]        = new[] { "RESP_RATE", "SPO2", "HEART_RATE" },
+        ["hydromorphone"]   = new[] { "RESP_RATE", "SPO2", "SYSTOLIC_BP" },
+        ["remifentanil"]    = new[] { "RESP_RATE", "SPO2", "HEART_RATE" },
+
+        // Sedatives / anaesthetics
+        ["propofol"]        = new[] { "RESP_RATE", "SPO2", "SYSTOLIC_BP", "HEART_RATE" },
+        ["midazolam"]       = new[] { "RESP_RATE", "SPO2" },
+        ["lorazepam"]       = new[] { "RESP_RATE", "SPO2" },
+        ["ketamine"]        = new[] { "HEART_RATE", "SYSTOLIC_BP", "RESP_RATE" },
+
+        // Antiarrhythmics
+        ["amiodarone"]      = new[] { "HEART_RATE", "SYSTOLIC_BP" },
+        ["adenosine"]       = new[] { "HEART_RATE" },
+        ["digoxin"]         = new[] { "HEART_RATE" },
+        ["atropine"]        = new[] { "HEART_RATE" },
+
+        // Anticoagulants
+        ["heparin"]         = new[] { "HEART_RATE" },
+
+        // Antipyretics
+        ["acetaminophen"]   = new[] { "TEMP_C" },
+        ["ibuprofen"]       = new[] { "TEMP_C" },
+
+        // Glucose management
+        ["insulin"]         = new[] { "GLUCOSE_MG_DL" },
+        ["dextrose"]        = new[] { "GLUCOSE_MG_DL" },
+        ["glucagon"]        = new[] { "GLUCOSE_MG_DL" },
+
+        // Corticosteroids
+        ["dexamethasone"]       = new[] { "GLUCOSE_MG_DL", "TEMP_C" },
+        ["methylprednisolone"]  = new[] { "GLUCOSE_MG_DL", "TEMP_C" },
+        ["hydrocortisone"]      = new[] { "GLUCOSE_MG_DL", "TEMP_C" },
+        ["prednisone"]          = new[] { "GLUCOSE_MG_DL", "TEMP_C" },
+
+        // Diuretics
+        ["furosemide"]      = new[] { "SYSTOLIC_BP", "DIASTOLIC_BP" },
+
+        // Bronchodilators
+        ["albuterol"]       = new[] { "HEART_RATE", "SPO2" }
+    };
+}